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The role of DNA base modifications

Abstract:

One day in 2006, while a postdoc in the Rockefeller University laboratory of Nathaniel Heintz, I had an unexpected eye-opener. Heintz showed me some electron microscopy images of Purkinje neuron nuclei in the murine cerebellum. They stunned me—the heterochromatin localization in the nucleus was different from anything I’d ever seen before. Rather than the dispersed, irregular patches with enrichment near nuclear membrane typical of many cells, nearly all the heterochromatin was in the cent...

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Publication status:
Published
Peer review status:
Reviewed (Other)

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Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
Publisher:
The Scientist, Inc. Publisher's website
Journal:
Scientist Journal website
Volume:
31
Issue:
9
Publication date:
2017-09-05
ISSN:
0890-3670
Pubs id:
pubs:731040
URN:
uri:27942732-571a-4ece-9d47-504ffb68e04e
UUID:
uuid:27942732-571a-4ece-9d47-504ffb68e04e
Local pid:
pubs:731040
Keywords:

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