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Journal article

Functional consequences of mutations in the autophagy genes in the pathogenesis of Crohn's disease.

Abstract:
Genome-wide association studies have highlighted a number of genes involved in autophagy, which are of potential importance in the pathogenesis of Crohn's disease (CD). The associated polymorphisms in ATG16L1 and IRGM have been confirmed, and functional studies have begun to shed light on how they link to CD pathogenesis. In this review we consider the most salient aspects of this rapidly expanding field.
Publication status:
Published

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Publisher copy:
10.1002/ibd.21832

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Molecular Medicine
Journal:
Inflammatory bowel diseases
Volume:
18
Issue:
4
Pages:
778-781
Publication date:
2012-04-05
DOI:
EISSN:
1536-4844
ISSN:
1078-0998
URN:
uuid:2792b681-e86e-4f2e-846d-ce7c77152cc0
Source identifiers:
170183
Local pid:
pubs:170183

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