Journal article
How could our genetics impact COVID-19 vaccine response?
- Abstract:
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Introduction: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has posed unprecedented global health challenges since its emergence in December 2019. The rapid availability of vaccines has been estimated to save millions of lives, but there is variation in how individuals respond to vaccines, influencing their effectiveness at an individual, and population level.
Areas covered: This review focuses on human genetic factors influencing the immune response and effectiveness of vaccines, highlighting the importance of associations across the HLA locus. Genome-Wide Association Studies (GWAS) and other genetic association analyses have identified statistically significant associations between specific HLA alleles including HLA-DRB1*13, DBQ1*06, and A*03 impacting antibody responses and the risk of breakthrough infections post-vaccination. Relationships between these associations and potential mechanisms and links with risks of natural infection or disease are explored, and this review concludes by emphasizing how understanding the mechanisms of these genetic determinants may inform the development of tailored vaccination strategies.
Expert opinion: Although complex, we believe these findings from the SARS-CoV2 pandemic offer a unique opportunity to understand the relationships between HLA and infection and vaccine response, with a goal of optimizing individual protection against COVID-19 in the ongoing pandemic, and possibly influencing wider vaccine development in the future.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
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(Preview, Accepted manuscript, pdf, 348.6KB, Terms of use)
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- Publisher copy:
- 10.1080/1744666x.2024.2346584
Authors
- Publisher:
- Taylor and Francis
- Journal:
- Expert Review of Clinical Immunology More from this journal
- Volume:
- 20
- Issue:
- 9
- Pages:
- 1027-1039
- Publication date:
- 2024-04-27
- Acceptance date:
- 2024-04-19
- DOI:
- EISSN:
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1744-8409
- ISSN:
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1744-666X
- Pmid:
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38676712
- Language:
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English
- Keywords:
- Pubs id:
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1993810
- Local pid:
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pubs:1993810
- Deposit date:
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2024-05-15
Terms of use
- Copyright holder:
- Informa UK Limited, trading as Taylor & Francis Group
- Copyright date:
- 2024
- Rights statement:
- © 2024 Informa UK Limited, trading as Taylor & Francis Group.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Taylor and Francis at https://dx.doi.org/10.1080/1744666x.2024.2346584
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