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Evidence for induction of DNA double strand breaks in the bystander response to targeted soft X-rays in CHO cells.

Abstract:

This study investigated the role of DNA double strand breaks and DNA base damage in radiation-induced bystander responses in Chinese hamster ovary (CHO) cell lines. Two CHO repair-deficient clones, xrs5 (DNA double strand break repair-deficient) and EM9 (DNA base excision repair-deficient) were used in addition to the wild type (CHO). The Gray Cancer Institute ultrasoft X-ray microprobe is a powerful tool for investigating the bystander response, because it permits the irradiation of only a s...

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Publication status:
Published

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Authors


Kashino, G More by this author
Schettino, G More by this author
Folkard, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Journal:
Mutation research
Volume:
556
Issue:
1-2
Pages:
209-215
Publication date:
2004-11-05
DOI:
EISSN:
1873-135X
ISSN:
0027-5107
URN:
uuid:274d2d2d-f0f7-42b7-8ff0-23958d9c668b
Source identifiers:
130981
Local pid:
pubs:130981

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