Journal article
The chondrocyte-intrinsic circadian clock is disrupted in human osteoarthritis
- Abstract:
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Peripheral clocks are essential for driving cell differentiation. In osteoarthritis, loss of the normal differentiated chondrocyte (cartilage cell) phenotype is causative of disease. We investigated whether clock gene expression differed in osteoarthritic compared to "healthy" chondrocytes and used RNAi to determine whether the differences observed could affect chondrocyte phenotype. Following serum shock, PER2 expression was significantly higher, whereas BMAL1 expression was significantly lo...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 92.5KB, Terms of use)
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- Publisher copy:
- 10.3109/07420528.2016.1158183
Authors
Bibliographic Details
- Publisher:
- Taylor and Francis
- Journal:
- Chronobiology International More from this journal
- Volume:
- 33
- Issue:
- 5
- Pages:
- 574-579
- Publication date:
- 2016-03-28
- DOI:
- EISSN:
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1525-6073
- ISSN:
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0742-0528
- Pmid:
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27019373
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:614003
- UUID:
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uuid:27416ae8-829d-4b3e-b616-d166e0a83b34
- Local pid:
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pubs:614003
- Source identifiers:
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614003
- Deposit date:
-
2016-11-25
Terms of use
- Copyright holder:
- Taylor & Francis
- Copyright date:
- 2016
- Notes:
-
This is the author accepted manuscript following peer review version of the article. The final version is
available online from Taylor & Francis at: https://doi.org/10.3109/07420528.2016.1158183
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