- Abstract:
-
We have investigated whether nucleoside drugs that induce or protect neurones against apoptosis might directly activate or inhibit mitochondrial permeability transition (mPT) since opening of the mPT pore can promote release of cytochrome c and apoptosis, while its closure can prevent these changes. We found that the pro-apoptotic pyrimidine analogues cytosine beta-D-arabinofuranoside and cytosine beta-D-arabinofuranoside 5'-triphosphate, which activated apoptosis in post-mitotic neurones wit...
Expand abstract - Publisher copy:
- 10.1016/s0006-2952(02)01181-4
-
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- Journal:
- Biochemical pharmacology
- Volume:
- 64
- Issue:
- 3
- Pages:
- 441-449
- Publication date:
- 2002-08-05
- DOI:
- EISSN:
-
1873-2968
- ISSN:
-
0006-2952
- URN:
-
uuid:2735d347-36cf-49f4-8203-0ebf573d01f6
- Source identifiers:
-
111147
- Local pid:
- pubs:111147
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues.
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