Journal article
Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues.
- Abstract:
-
We have investigated whether nucleoside drugs that induce or protect neurones against apoptosis might directly activate or inhibit mitochondrial permeability transition (mPT) since opening of the mPT pore can promote release of cytochrome c and apoptosis, while its closure can prevent these changes. We found that the pro-apoptotic pyrimidine analogues cytosine beta-D-arabinofuranoside and cytosine beta-D-arabinofuranoside 5'-triphosphate, which activated apoptosis in post-mitotic neurones wit...
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- Publisher copy:
- 10.1016/s0006-2952(02)01181-4
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Authors
Bibliographic Details
- Journal:
- Biochemical pharmacology
- Volume:
- 64
- Issue:
- 3
- Pages:
- 441-449
- Publication date:
- 2002-08-01
- DOI:
- EISSN:
-
1873-2968
- ISSN:
-
0006-2952
- Source identifiers:
-
111147
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:111147
- UUID:
-
uuid:2735d347-36cf-49f4-8203-0ebf573d01f6
- Local pid:
- pubs:111147
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2002
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