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Altered primary CD8+ T cell response to a modified virus Ankara(MVA)-vectored vaccine in the absence of CD4+ T cell help.

Abstract:

T cell receptor-transgenic F5 mice were used to assess primary CD8+ T cell responses to a modified virus Ankara (MVA)-vectored vaccine in the absence of CD4+ T cell help. Naive, CD8-enriched, CFSE-labelled F5 cells were transferred into normal or CD4+ cell-depleted mice and the mice were vaccinated with MVA.HIVA-NP. At different time points during the primary response, F5 cells were re-isolated and analysed on divisional basis for a number of parameters. We demonstrated that the primary CD8+ ...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200526284

Authors


Estcourt, MJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Journal:
European journal of immunology
Volume:
35
Issue:
12
Pages:
3460-3467
Publication date:
2005-12-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:27343ce3-c3d5-49be-af99-8712cce9a612
Source identifiers:
33279
Local pid:
pubs:33279

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