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Journal article

Accessory ESCRT-III proteins are conserved and selective regulators of Rab11a-exosome formation

Abstract:

Exosomes are secreted nanovesicles with potent signalling activity that are initially formed as intraluminal vesicles (ILVs) in late Rab7-positive multivesicular endosomes, and also in recycling Rab11a-positive endosomes, particularly under some forms of nutrient stress. The core proteins of the Endosomal Sorting Complex Required for Transport (ESCRT) participate in exosome biogenesis and ILV-mediated destruction of ubiquitinylated cargos. Accessory ESCRT-III components have reported roles in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/jev2.12311

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/R004862/1
BB/N016300/1
BB/K017462/1
Publisher:
Wiley
Journal:
Journal of Extracellular Vesicles More from this journal
Volume:
12
Issue:
3
Article number:
12311
Publication date:
2023-03-05
Acceptance date:
2023-02-09
DOI:
EISSN:
2001-3078
Language:
English
Keywords:
Pubs id:
1328797
Local pid:
pubs:1328797
Deposit date:
2023-02-17

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