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Assessing methods to specify the target difference for a randomised controlled trial: DELTA (Difference ELicitation in TriAls) review.

Abstract:

BACKGROUND: The randomised controlled trial (RCT) is widely considered to be the gold standard study for comparing the effectiveness of health interventions. Central to the design and validity of a RCT is a calculation of the number of participants needed (the sample size). The value used to determine the sample size can be considered the 'target difference'. From both a scientific and an ethical standpoint, selecting an appropriate target difference is of crucial importance. Determination of...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3310/hta18280

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, CSM
Adewuyi, TE More by this author
Harrild, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, CSM
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Medical Research Council More from this funder
National Institute for Health Research More from this funder
Publisher:
NIHR Health Technology Assessment Programme Publisher's website
Journal:
Health technology assessment (Winchester, England) Journal website
Volume:
18
Issue:
28
Pages:
v-175
Publication date:
2014-05-05
DOI:
EISSN:
2046-4924
ISSN:
1366-5278
URN:
uuid:2732bdcd-374e-4964-bee1-3f5bb4ca4e8a
Source identifiers:
465181
Local pid:
pubs:465181

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