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Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p.

Abstract:

Genome-wide association studies have identified a region on chromosome 9p that is associated with coronary artery disease (CAD). The region is also associated with type 2 diabetes (T2D), a risk factor for CAD, although different SNPs were reported to be associated to each disease in separate studies. We have undertaken a case-control study in 4251 CAD cases and 4443 controls in four European populations using previously reported ('literature') and tagging SNPs. We replicated the literature SN...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddm352

Authors


Broadbent, HM More by this author
Lorkowski, S More by this author
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Journal:
Human molecular genetics
Volume:
17
Issue:
6
Pages:
806-814
Publication date:
2008-03-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:272177a4-4b85-4916-9576-a47ffc57fd7b
Source identifiers:
49248
Local pid:
pubs:49248

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