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Thesis

Antigenic variation and its evolution in P. falciparum malaria

Abstract:

This thesis investigates antigenic variation and its evolution in Plasmodium falciparum, the cause of the most deadly form of human malaria. Antigenic variation is a strategy for evading immunity by switching between antigenic variants during infection. In P. falciparum, such variable antigens confer different binding phenotypes that may affect parasite survival and have also been linked to pathology. Here, a new statistical method is described for determining the switching patterns that u...

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Institution:
University of Oxford
Research group:
Evolutionary Ecology of Infectious Disease
Oxford college:
Linacre College
Department:
Mathematical,Physical & Life Sciences Division - Zoology

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:271b8ef9-4e14-42e3-80e6-5584119e20ca
Local pid:
ora:8295

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