Cytoplasmic activated protein kinase Akt regulates lipid-droplet accumulation in Drosophila nurse cells.

Journal article

The insulin/insulin-like growth factor signalling (IIS) cascade performs a broad range of evolutionarily conserved functions, including the regulation of growth, developmental timing and lifespan, and the control of sugar, protein and lipid metabolism. Recently, these functions have been genetically dissected in the fruit fly Drosophila melanogaster, revealing a crucial role for cell-surface activation of the downstream effector kinase Akt in many of these processes. However, the mechanisms r...

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Authors: Vereshchagina, N; Wilson, C

• Publication status: Published
• Journal: Development (Cambridge, England)
• Volume: 133
• Issue: 23
• Pages: 4731-4735
• Publication date: 2006-12-01
• DOI: 10.1242/dev.02659
• EISSN: 1477-9129
• ISSN: 0950-1991
• Language: English
• Keywords: Mutation; Signal Transduction; Animals, Genetically Modified; Ovary; Animals; Female; Drosophila melanogaster; Genes, Insect; Drosophila Proteins; Proto-Oncogene Proteins c-akt; Insulin; Models, Biological; PTEN Phosphohydrolase; Somatomedins; Lipid Metabolism