- Abstract:
-
Both the ERCC1-XPF complex and the proteins involved in homoIogous recombination (HR) have critical roles in inter-strand cross-link (ICL) repair. Here, we report that mitomycin C-induced lesions inhibit replication fork elongation. Furthermore, mitomycin C-induced DNA double-strand breaks (DSBs) are the result of the collapse of ICL-stalled replication forks. These are not formed through replication run off, as we show that mitomycin C or cisplatin-induced DNA lesions are not incised by glob...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.8MB)
-
- Publisher copy:
- 10.1093/nar/gkp705
-
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- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic Acids Research Journal website
- Volume:
- 37
- Issue:
- 19
- Pages:
- 6400–6413
- Publication date:
- 2009-08-05
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
- URN:
-
uuid:26fc3f73-1539-4cd5-8191-8018b250d411
- Local pid:
- ora:8067
- Language:
- English
- Subjects:
- Copyright holder:
- Al-Minawi et al.
- Copyright date:
- 2009
- Notes:
- © 2009 Al-Minawi et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links
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Swedish Cancer Society
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Swedish Children's Cancer Foundation
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Swedish Research Council
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Swedish Pain Relief Foundation
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Medical Research Council
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