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The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links

Abstract:

Both the ERCC1-XPF complex and the proteins involved in homoIogous recombination (HR) have critical roles in inter-strand cross-link (ICL) repair. Here, we report that mitomycin C-induced lesions inhibit replication fork elongation. Furthermore, mitomycin C-induced DNA double-strand breaks (DSBs) are the result of the collapse of ICL-stalled replication forks. These are not formed through replication run off, as we show that mitomycin C or cisplatin-induced DNA lesions are not incised by glob...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkp705

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Institution:
University of Oxford
Department:
Medical Sciences Division - Radiation,Oncology and Biology
Role:
Author
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Institution:
University of Oxford
Department:
Medical Sciences Division - Radiation,Oncology and Biology
Role:
Author
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Swedish Cancer Society More from this funder
Swedish Children's Cancer Foundation More from this funder
Swedish Research Council More from this funder
Swedish Pain Relief Foundation More from this funder
Medical Research Council More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
37
Issue:
19
Pages:
6400–6413
Publication date:
2009-08-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:26fc3f73-1539-4cd5-8191-8018b250d411
Local pid:
ora:8067
Language:
English
Subjects:

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