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Journal article

Cellular penetration and nuclear importation properties of 111In-labeled and 123I-labeled HIV-1 tat peptide immunoconjugates in BT-474 human breast cancer cells.

Abstract:

INTRODUCTION: Our objective was to compare the cell penetration and nuclear importation properties of 111In-labeled and 123I-labeled immunoconjugates (ICs) composed of 16-mer peptides (GRKKRRQRRRPPQGYG) derived from HIV-1 transactivator of transcription (tat) protein and anti-mouse IgG (mIgG) in BT-474 breast cancer (BC) cells. METHODS: [111In]tat ICs were constructed by site-specific conjugation of tat peptides to NaIO4(-)-oxidized carbohydrates in the Fc domain of diethylenetriaminepentaac...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
Journal:
Nuclear medicine and biology
Volume:
34
Issue:
1
Pages:
37-46
Publication date:
2007-01-05
DOI:
EISSN:
1872-9614
ISSN:
0969-8051
URN:
uuid:26fa28e3-d2d2-4522-beb2-e507ea6d55bb
Source identifiers:
257729
Local pid:
pubs:257729

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