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Anticancer DNA intercalators cause p53-dependent mitochondrial DNA nucleoid re-modelling.

Abstract:

Many anticancer drugs, such as doxorubicin (DXR), intercalate into nuclear DNA of cancer cells, thereby inhibiting their growth. However, it is not well understood how such drugs interact with mitochondrial DNA (mtDNA). Using cell and molecular studies of cultured cells, we show that DXR and other DNA intercalators, such as ethidium bromide, can rapidly intercalate into mtDNA within living cells, causing aggregation of mtDNA nucleoids and altering the distribution of nucleoid proteins. Remode...

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Publication status:
Published

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Publisher copy:
10.1038/onc.2009.242

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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Journal:
Oncogene
Volume:
28
Issue:
44
Pages:
3880-3891
Publication date:
2009-11-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:26e7c0c1-f7b3-43a0-baf8-d87fa639b7fe
Source identifiers:
248251
Local pid:
pubs:248251

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