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Journal article

Does anti-EGFR therapy improve outcome in advanced colorectal cancer? A systematic review and meta-analysis.

Abstract:

BACKGROUND: Randomised controlled trials (RCTs) of anti-EGFR monoclonal antibodies (MAb) in patients with advanced colorectal cancer (aCRC) have reported conflicting results. METHODS: A systematic review of RCTs comparing standard treatments±anti-EGFR MAbs was conducted. Hazard ratios (HR) for progression-free (PFS) and overall survival (OS) were derived for patients with wild-type (WT) and mutant KRAS. Prespecified analyses were conducted for line of treatment, MAb used, chemotherapy regimen...

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Publication status:
Published

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Publisher copy:
10.1016/j.ctrv.2011.11.002

Authors


Tierney, JF More by this author
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Journal:
Cancer treatment reviews
Volume:
38
Issue:
6
Pages:
618-625
Publication date:
2012-10-05
DOI:
EISSN:
1532-1967
ISSN:
0305-7372
URN:
uuid:26e1c422-db2c-4d17-af00-b11bb464eee2
Source identifiers:
216464
Local pid:
pubs:216464

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