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THEMIS: Two models, different thresholds.

Abstract:

THEMIS, a recently identified T-lineage-restricted protein, is the founding member of a large metazoan protein family. Gene inactivation studies have revealed a critical requirement for THEMIS during thymocyte positive selection, implicating THEMIS in signaling downstream of the T cell antigen receptor (TCR), but the mechanistic underpinnings of THEMIS function have remained elusive. A previous model posited that THEMIS prevents thymocytes from inappropriately crossing the positive/negative s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.it.2017.06.006

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Department:
Corpus Christi College
Role:
Author
French National Institute of Health and Medical Research More from this funder
Medical Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Trends in Immunology Journal website
Publication date:
2017-07-05
DOI:
EISSN:
1471-4981
ISSN:
1471-4906
Pubs id:
pubs:708009
URN:
uri:26dc6d21-3c12-4ad1-a6f6-a71a86396c30
UUID:
uuid:26dc6d21-3c12-4ad1-a6f6-a71a86396c30
Local pid:
pubs:708009
Language:
English
Keywords:

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