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Thesis

Altered contractile mechanics and Ca2+ handling contribute to cardiomyopathy pathogenesis

Abstract:

Mutations in genes encoding sarcomeric proteins are the most common cause of inherited cardiomyopathies. However, cardiac disease caused by mutations in non-sarcomeric proteins exhibit remarkably similar phenotypes, suggesting that common modes of pathogenesis might exist. It is of particular interest whether non-sarcomeric mutations result in impaired contractile function akin to sarcomeric diseases. Accordingly, this thesis describes the effect of cardiomyopathy-causing mutations to an e...

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Institution:
University of Oxford
Research group:
Hugh Watkins, Charles Redwood
Oxford college:
St John's College
Department:
Medical Sciences Division - Cardiovascular Medicine

Contributors

Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Cameron Turtle
Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:26d4cbaa-bb2f-4108-9659-123dc0cd96cd
Local pid:
ora:12241
Language:
English
Keywords:
Subjects:

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