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Type 2 fiber predominance in Lambert-Eaton myasthenic syndrome.

Abstract:

Serial muscle biopsies in a noncarcinomatous case of Lambert-Eaton myasthenic syndrome (LEMS) have shown progressive atrophy and loss of type 1 fibers, resulting in overwhelming type 2 predominance. A similar abnormality was found in a single biopsy from a second case of LEMS without associated carcinoma. Review of the literature suggests that type 2 fiber predominance has been observed in at least one other biopsied case. Interference with transmitter release caused by anti-voltage-gated cal...

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Publisher copy:
10.1002/mus.880140705

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Newsom-Davis, J More by this author
Journal:
Muscle and nerve
Volume:
14
Issue:
7
Pages:
625-632
Publication date:
1991-07-05
DOI:
EISSN:
1097-4598
ISSN:
0148-639X
URN:
uuid:26cf3486-8a71-4f6b-b18b-9e591173fdf7
Source identifiers:
248111
Local pid:
pubs:248111

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