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Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas.

Abstract:

BACKGROUND: HIF-1 deficiency has marked effects on tumour glycolysis and growth. We therefore investigated the consequences of HIF-1 deficiency in mice, using the well established Hepa-1 wild-type (WT) and HIF-1β-deficient (c4) model. These mechanisms could be clinically relevant, since HIF-1 is now a therapeutic target. METHODS: Hepa-1 WT and c4 tumours grown in vivo were analysed by 18FDG-PET and 19FDG Magnetic Resonance Spectroscopy for glucose uptake; by HPLC for adenine nucleotides; by i...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1471-2407-11-198

Authors


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Cancer Research UK More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
BMC Cancer Journal website
Volume:
11
Issue:
1
Pages:
Article: 198
Publication date:
2011-01-01
DOI:
EISSN:
1471-2407
ISSN:
1471-2407
URN:
uuid:26b7ef33-0a0c-4870-a363-ea1361e183a2
Source identifiers:
220131
Local pid:
pubs:220131

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