Journal article
Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas.
- Abstract:
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BACKGROUND: HIF-1 deficiency has marked effects on tumour glycolysis and growth. We therefore investigated the consequences of HIF-1 deficiency in mice, using the well established Hepa-1 wild-type (WT) and HIF-1β-deficient (c4) model. These mechanisms could be clinically relevant, since HIF-1 is now a therapeutic target. METHODS: Hepa-1 WT and c4 tumours grown in vivo were analysed by 18FDG-PET and 19FDG Magnetic Resonance Spectroscopy for glucose uptake; by HPLC for adenine nucleotides; by i...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, doc, 823.0KB)
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- Publisher copy:
- 10.1186/1471-2407-11-198
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Authors
Contributors
+ Harris, A
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Funding
Cancer Research UK
More from this funder
Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- BMC Cancer Journal website
- Volume:
- 11
- Issue:
- 1
- Article number:
- 198
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
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1471-2407
- ISSN:
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1471-2407
- Source identifiers:
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220131
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:220131
- UUID:
-
uuid:26b7ef33-0a0c-4870-a363-ea1361e183a2
- Local pid:
- pubs:220131
- Deposit date:
- 2013-11-16
Terms of use
- Copyright holder:
- Golinska et al
- Copyright date:
- 2011
- Notes:
- © 2011 Golinska et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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