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Journal article

Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype.

Abstract:

BACKGROUND: Tumours contain hypoxic regions that select for an aggressive cell phenotype; tumour hypoxia induces metastasis-associated genes. Treatment refractory patients with metastatic cancer show increased numbers of circulating tumour cells (CTCs), which are also associated with disease progression. The aim of this study was to examine the as yet unknown relationship between hypoxia and CTCs. METHODS: We generated human MDA-MB-231 orthotopic xenografts and, using a new technology, isola...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6605491

Authors


Powell, AA More by this author
Montgomery, KD More by this author
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Journal:
British journal of cancer
Volume:
102
Issue:
3
Pages:
561-569
Publication date:
2010-02-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:26ae9161-bfd6-465c-b530-87f1fb5015ce
Source identifiers:
125254
Local pid:
pubs:125254

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