Journal article
Nucleocytoplasmic distribution of human RNA-editing enzyme ADAR1 is modulated by double-stranded RNA-binding domains, a leucine-rich export signal, and a putative dimerization domain.
- Abstract:
-
The human RNA-editing enzyme adenosine deaminase that acts on RNA (ADAR1) is expressed in two versions. A longer 150-kDa protein is interferon inducible and can be found both in the nucleus and cytoplasm. An amino-terminally truncated 110-kDa version, in contrast, is constitutively expressed and predominantly nuclear. In the absence of transcription, however, the shorter protein is also cytoplasmic and thus displays the hallmarks of a shuttling protein. The nuclear localization signal (NLS) o...
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- Publisher copy:
- 10.1091/mbc.e02-03-0161
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Bibliographic Details
- Journal:
- Molecular biology of the cell
- Volume:
- 13
- Issue:
- 11
- Pages:
- 3822-3835
- Publication date:
- 2002-11-01
- DOI:
- EISSN:
-
1939-4586
- ISSN:
-
1059-1524
- Source identifiers:
-
334664
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:334664
- UUID:
-
uuid:26a19e2a-8493-43d4-bf01-62692c0cab43
- Local pid:
- pubs:334664
- Deposit date:
- 2013-11-17
Terms of use
- Copyright date:
- 2002
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