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Thesis

Identifying novel substrates of salt-inducible kinase 2

Abstract:

Salt-inducible kinase 2 (SIK2) has previously been identified as a potential therapeutic target in high-grade serous ovarian cancer. Depletion of SIK2 sensitises ovarian cancers to paclitaxel treatment both in vitro and in xenograft models. In patients, increased tumour SIK2 expression is associated with paclitaxel resistance and correlates with increased risk of cancer progression following paclitaxel treatment. Although high-grade serous tumours are highly chemosensitive, 80 - 9...

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Division:
MSD
Department:
Women's and Reproductive Health
Department:
University of Oxford
Role:
Author

Contributors

Department:
University of Oxford
Role:
Supervisor
Department:
University of Oxford
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:269df8a2-04a4-4653-9aab-0facf4cbf12f
Deposit date:
2016-07-10

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