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Identifying novel substrates of salt-inducible kinase 2

Abstract:

Salt-inducible kinase 2 (SIK2) has previously been identified as a potential therapeutic target in high-grade serous ovarian cancer. Depletion of SIK2 sensitises ovarian cancers to paclitaxel treatment both in vitro and in xenograft models. In patients, increased tumour SIK2 expression is associated with paclitaxel resistance and correlates with increased risk of cancer progression following paclitaxel treatment. Although high-grade serous tumours are highly chemosensitive, 80 - 9...

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Department:
University of Oxford
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Department:
University of Oxford
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Department:
University of Oxford
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Grant:
1145459
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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