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Synonymous substitution rates predict HIV disease progression as a result of underlying replication dynamics

Abstract:

Upon HIV transmission, some patients develop AIDS in only a few months, while others remain disease free for 20 or more years. This variation in the rate of disease progression is poorly understood and has been attributed to host genetics, host immune responses, co-infection, viral genetics, and adaptation. Here, we develop a new "relaxed-clock" phylogenetic method to estimate absolute rates of synonymous and nonsynonymous substitution through time. We identify an unexpected association betwe...

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Authors


Kosakovsky Pond, SL More by this author
Drummond, AJ More by this author
Shapiro, B More by this author
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Journal:
PLoS Computational Biology
Volume:
3
Issue:
2
Pages:
0282-0292
Publication date:
2007-02-05
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
URN:
uuid:2699111c-5904-41ec-aacf-a5994e6e9cfd
Source identifiers:
210951
Local pid:
pubs:210951
Language:
English

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