Journal article

Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages

Abstract:: Oligonucleotides hold great promise as therapeutic agents but poor bioavailability limits their utility. Hence, new analogues with improved cell uptake are urgently needed. Here, we report the synthesis and physical study of reduced-charge oligonucleotides containing artificial LNA-sulfamate and sulfamide linkages combined with 2′-O-methyl sugars and phosphorothioate backbones. These oligonucleotides have high affinity for RNA and excellent nuclease resistance.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Zengin Kurt, B., Dhara, D., El-Sagheer, A. H., & Brown, T. (2024). Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages. Organic Letters, 26(19), 4137–4141.

MLA Style

Zengin Kurt, B., et al. “Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages.” Organic Letters, vol. 26, no. 19, American Chemical Society, 2024, pp. 4137–41.

Chicago Style

Zengin Kurt, B, D Dhara, AH El-Sagheer, and T Brown. 2024. “Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages.” Organic Letters 26 (19): 4137–41.
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Files:: Zengin_Kurt_et_al_2024_Synthesis_and_Properties.pdf

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Publisher copy:: 10.1021/acs.orglett.4c01232

Authors

+ Zengin Kurt, B More by this author

Institution:: University of Oxford
Division:: HUMS
Department:: Classics Faculty
Sub department:: Chemistry Research Laboratory
Role:: Author
ORCID:: 0000-0002-4663-5402

+ Dhara, D More by this author

Institution:: University of Oxford
Division:: HUMS
Department:: Classics Faculty
Sub department:: Chemistry Research Laboratory
Role:: Author

+ El-Sagheer, AH More by this author

Institution:: University of Oxford
Division:: HUMS
Department:: Classics Faculty
Sub department:: Chemistry Research Laboratory
Role:: Author

+ Brown, T More by this author

Institution:: University of Oxford
Division:: HUMS
Department:: Classics Faculty
Sub department:: Chemistry Research Laboratory
Role:: Author
ORCID:: 0000-0002-6538-3036

+ Medical Research Council More from this funder

Funder identifier:: https://ror.org/03x94j517

Publisher:: American Chemical Society
Journal:: Organic Letters More from this journal
Volume:: 26
Issue:: 19
Pages:: 4137-4141
Publication date:: 2024-05-08
Acceptance date:: 2024-05-07
DOI:: 10.1021/acs.orglett.4c01232
EISSN:: 1523-7052
ISSN:: 1523-7060

Language:: English
Pubs id:: 1995618
Local pid:: pubs:1995618
Source identifiers:: 1979410
Deposit date:: 2024-07-20

Terms of use

Copyright date:: 2024

Licence:: CC Attribution (CC BY)

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