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Neurotransmitter-induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin.

Abstract:

Neurotransmitters and hormones such as somatostatin, galanin, and adrenalin reduce insulin secretion. Their inhibitory action involves direct interference with the exocytotic machinery. We have examined the molecular processes underlying this effect using high resolution measurements of cell capacitance. Suppression of exocytosis was maximal at concentrations that did not cause complete inhibition of glucose-stimulated electrical activity. This action was dependent on activation of G proteins...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Journal:
Neuron
Volume:
17
Issue:
3
Pages:
513-522
Publication date:
1996-09-05
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:267c3be7-aa52-47f4-8579-2caceeaf668a
Source identifiers:
12336
Local pid:
pubs:12336

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