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Expansion of circulating NKG2D+ effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosis.

Abstract:

Expansion of circulating CD28- T-cells reminiscent of effector memory T-cells (T(EM)) has been reported in Wegener's granulomatosis (WG) recently. To investigate the role of T(EM) in WG, we analyzed the expression of the activating NK-receptor NKG2D and its ligand MIC on circulating T(EM) and in granulomatous lesions, respectively. NKG2D was anomalously expressed and preferentially detected on circulating CD4+CD28- T(EM) in WG. Compared to healthy controls, T(EM) display a more activated phen...

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Publication status:
Published

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Publisher copy:
10.1016/j.clim.2007.12.004

Authors


Capraru, D More by this author
Müller, A More by this author
Csernok, E More by this author
Holl-Ulrich, K More by this author
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Journal:
Clinical immunology (Orlando, Fla.)
Volume:
127
Issue:
2
Pages:
144-150
Publication date:
2008-05-05
DOI:
EISSN:
1521-7035
ISSN:
1521-6616
URN:
uuid:26664391-79e1-45d9-9db2-681bd5b3515f
Source identifiers:
20621
Local pid:
pubs:20621

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