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Deficiency of lymphocyte function-associated antigen 3 (LFA-3) in paroxysmal nocturnal hemoglobinuria. Functional correlates and evidence for a phosphatidylinositol membrane anchor.

Abstract:

Lymphocyte function-associated antigen 3 (LFA-3) is a widely distributed cell surface glycoprotein that binds to the T lymphocyte CD2 surface glycoprotein. This interaction mediates CTL-target cell conjugate formation and adhesion of thymocytes to thymic epithelial cells. CD2 is also the E rosette receptor of T lymphocytes and mediates rosetting with autologous E by binding to LFA-3. We describe deficient expression of LFA-3 on E from paroxysmal nocturnal hemoglobinuria (PNH) patients. PNH is...

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Publisher copy:
10.1084/jem.166.4.1011

Authors


Selvaraj, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Springer, TA More by this author
Journal:
The Journal of experimental medicine
Volume:
166
Issue:
4
Pages:
1011-1025
Publication date:
1987-10-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:265d79ad-c641-4303-9023-5b6a5ec38bb1
Source identifiers:
482723
Local pid:
pubs:482723

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