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Effects of microcystin-LR in isolated perfused rat kidney.

Abstract:

Microcystin is a hepatotoxic peptide which inhibits protein phosphatase types 1 and 2A. The objective of the present study was to evaluate the physiopathologic effects of microcystin-LR in isolated perfused rat kidney. Adult Wistar rats (N = 5) of both sexes (240-280 g) were utilized. Microcystin-LR (1 microg/ml) was perfused over a period of 120 min, during which samples of urine and perfusate were collected at 10-min intervals to determine the levels of inulin, sodium, potassium and osmolal...

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Journal:
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.]
Volume:
32
Issue:
8
Pages:
985-988
Publication date:
1999-08-05
DOI:
EISSN:
1414-431X
ISSN:
0100-879X
URN:
uuid:2646ec71-ad67-4839-9aa1-b1f2b0c50bc1
Source identifiers:
3595
Local pid:
pubs:3595

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