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Effect of cytokines on HLA-DR and IL-1 production by a monocytic tumour, THP-1.

Abstract:

The monocytic tumour, THP-1, expresses many of the properties of monocytes, both by cell surface staining and its capacity to produce monokines. It was used as a source of homogenous monocytic cells as a model to determine whether a variety of highly purified or recombinant cytokines could induce HLA-DR expression and the production of interleukin-1 (IL-1). Interferon-gamma (IFN-gamma) alone induced HLA-DR. Tumour necrosis factor (TNF), lymphotoxin (LT) and granulocyte-macrophage colony-stimu...

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Publication status:
Published

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Authors


Portillo, G More by this author
Chantry, D More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Immunology
Volume:
66
Issue:
2
Pages:
170-175
Publication date:
1989-02-05
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:262ecd99-264d-4bc7-b173-dad3738d9491
Source identifiers:
481700
Local pid:
pubs:481700

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