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A transposon insertion in the Escherichia coli uvrC gene; UvrC protein is absolutely required for the incision step in excision repair.

Abstract:

The formation of single-stranded breaks in DNA following UV irradiation is assessed in uvrC34 mutants. By altering the SOS DNA-repair system, either by additional mutations or by using drugs affecting transcription or translation, it is shown that such single-stranded breaks require one or more DNA-damage-inducible functions. A UV-sensitive strain is characterized as carrying a Tn10 insertion into the uvrC gene. The absence of post-irradiation incision in this strain demonstrates that uvrC fu...

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Authors


Walters, RG More by this author
Wilbraham, HO More by this author
Forster, JW More by this author
Journal:
Journal of general microbiology
Volume:
134
Issue:
2
Pages:
403-412
Publication date:
1988-02-05
ISSN:
0022-1287
URN:
uuid:262d01e0-19b0-4a5f-b49d-665946533724
Source identifiers:
375260
Local pid:
pubs:375260

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