Modulation of fibroblast growth factor-2 receptor binding, signaling, and mitogenic activity by heparin-mimicking polysulfonated compounds.

Liekens, S; Leali, D; Neyts, J; Esnouf, R; Rusnati, M; Dell'Era, P; Maudgal, PC; De Clercq, E; Presta, M

Abstract:

Basic fibroblast growth factor (FGF-2) interacts with high-affinity tyrosine-kinase fibroblast growth factor receptors (FGFRs) and low-affinity heparan sulfate proteoglycans (HSPGs) in target cells. Both interactions are required for FGF-2-mediated biological responses. Here we report the FGF-2 antagonist activity of novel synthetic sulfonic acid polymers with distinct chemical structures and molecular masses (MMs). PAMPS [poly(2-acrylamido-2-methyl-1-propanesulfonic acid)], (MM approximately...

Expand abstract

Publication status:

Published

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Liekens, S., Leali, D., Neyts, J., Esnouf, R., Rusnati, M., Dell'Era, P., Maudgal, P. C., De Clercq, E., & Presta, M. (1999). Modulation of fibroblast growth factor-2 receptor binding, signaling, and mitogenic activity by heparin-mimicking polysulfonated compounds. Molecular Pharmacology, 56(1), 204–213.

MLA Style

Liekens, S., et al. “Modulation of Fibroblast Growth Factor-2 Receptor Binding, Signaling, and Mitogenic Activity by Heparin-Mimicking Polysulfonated Compounds.” Molecular Pharmacology, vol. 56, no. 1, Molecular pharmacology, 1999, pp. 204–13.

Chicago Style

Liekens, S, D Leali, J Neyts, R Esnouf, M Rusnati, P Dell'Era, PC Maudgal, E De Clercq, and M Presta. 1999. “Modulation of Fibroblast Growth Factor-2 Receptor Binding, Signaling, and Mitogenic Activity by Heparin-Mimicking Polysulfonated Compounds.” Molecular Pharmacology 56 (1): 204–13.
Tweet
Print

Authors

Liekens, S More by this author

Leali, D More by this author

Neyts, J More by this author

Esnouf, R More by this author

Rusnati, M More by this author

Expand authors...

Bibliographic Details

Journal:: Molecular pharmacology
Volume:: 56
Issue:: 1
Pages:: 204-213
Publication date:: 1999-07-05
EISSN:: 1521-0111
ISSN:: 0026-895X
URN:: uuid:261ad1fd-ee27-4874-b365-17ea7ee01c51
Source identifiers:: 5800
Local pid:: pubs:5800

Item Description

Language:: English
Keywords:: Heparin

Receptor Protein-Tyrosine Kinases

Animals

Molecular Mimicry

Polymers

CHO Cells

Signal Transduction

Models, Molecular

Receptors, Fibroblast Growth Factor

Endothelium

Binding, Competitive

Receptor, Fibroblast Growth Factor, Type 2

Computer Simulation

Sulfonic Acids

Cattle

Trypsin

Cricetinae

Cells, Cultured

Sulfur Compounds

Terms of use

License:: Terms and Conditions of Use for Oxford University Research Archive

Views & Downloads

Metrics

If you are the owner of this record, you can report an update to it here: Report update to this record