Journal article
Modulation of fibroblast growth factor-2 receptor binding, signaling, and mitogenic activity by heparin-mimicking polysulfonated compounds.
- Abstract:
-
Basic fibroblast growth factor (FGF-2) interacts with high-affinity tyrosine-kinase fibroblast growth factor receptors (FGFRs) and low-affinity heparan sulfate proteoglycans (HSPGs) in target cells. Both interactions are required for FGF-2-mediated biological responses. Here we report the FGF-2 antagonist activity of novel synthetic sulfonic acid polymers with distinct chemical structures and molecular masses (MMs). PAMPS [poly(2-acrylamido-2-methyl-1-propanesulfonic acid)], (MM approximately...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Molecular pharmacology
- Volume:
- 56
- Issue:
- 1
- Pages:
- 204-213
- Publication date:
- 1999-07-05
- EISSN:
-
1521-0111
- ISSN:
-
0026-895X
- URN:
-
uuid:261ad1fd-ee27-4874-b365-17ea7ee01c51
- Source identifiers:
-
5800
- Local pid:
- pubs:5800
Item Description
- Language:
- English
- Keywords:
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- Copyright date:
- 1999
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