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Immunomodulatory effects of etanercept in a model of brain injury act through attenuation of the acute-phase response.

Abstract:

TNF-alpha has proved to be a successful target in the treatment of many peripheral inflammatory diseases, but the same interventions worsen immune-mediated CNS disease. However, anti-TNF-alpha strategies may offer promise as therapy for non-immune CNS injury. In this study, we have microinjected IL-1beta or lipopolysaccharide (LPS) into the rat brain as a simple model of brain injury and have systemically administered the TNF-alpha antagonist etanercept to discover whether hepatic TNF-alpha, ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Farrands, R More by this author
Holbrook, J More by this author
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Journal:
Journal of neurochemistry
Volume:
103
Issue:
6
Pages:
2245-2255
Publication date:
2007-12-05
DOI:
EISSN:
1471-4159
ISSN:
0022-3042
URN:
uuid:2610a9c9-d79e-4942-8e46-ca6f958241b7
Source identifiers:
185292
Local pid:
pubs:185292

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