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Design principles for rapid folding of knotted DNA nanostructures.

Abstract:

Knots are some of the most remarkable topological features in nature. Self-assembly of knotted polymers without breaking or forming covalent bonds is challenging, as the chain needs to be threaded through previously formed loops in an exactly defined order. Here we describe principles to guide the folding of highly knotted single-chain DNA nanostructures as demonstrated on a nano-sized square pyramid. Folding of knots is encoded by the arrangement of modules of different stability based on de...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms10803

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
Gradišar, H More by this author
Bašić, N More by this author
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International Centre for Genetic Engineering and Biotechnology More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature communications Journal website
Volume:
7
Pages:
10803
Publication date:
2016-02-05
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
URN:
uuid:260e4002-9da6-41f4-aa21-a56d1621e9a8
Source identifiers:
606055
Local pid:
pubs:606055
Language:
English

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