- Abstract:
-
We demonstrate here that the E2F1 induced by DNA damage can bind to and promote the apoptotic function of p53 via the cyclin A binding site of E2F1. This function of E2F1 does not require its DP-1 binding, DNA binding, or transcriptional activity and is independent of mdm2. All the cyclin A binding E2F family members can interact and cooperate with p53 to induce apoptosis. This suggests a novel role for E2F in regulating apoptosis in response to DNA damage. Cyclin A, but not cyclin E, prevent...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/mcb.22.1.78-93.2002
-
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- Journal:
- Molecular and cellular biology
- Volume:
- 22
- Issue:
- 1
- Pages:
- 78-93
- Publication date:
- 2002-01-05
- DOI:
- EISSN:
-
1098-5549
- ISSN:
-
0270-7306
- URN:
-
uuid:260a5b1f-cd87-47bd-b8d8-24a95e83ed33
- Source identifiers:
-
83952
- Local pid:
- pubs:83952
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage.
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