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Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage.

Abstract:

We demonstrate here that the E2F1 induced by DNA damage can bind to and promote the apoptotic function of p53 via the cyclin A binding site of E2F1. This function of E2F1 does not require its DP-1 binding, DNA binding, or transcriptional activity and is independent of mdm2. All the cyclin A binding E2F family members can interact and cooperate with p53 to induce apoptosis. This suggests a novel role for E2F in regulating apoptosis in response to DNA damage. Cyclin A, but not cyclin E, prevent...

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Publication status:
Published

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Publisher copy:
10.1128/mcb.22.1.78-93.2002

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Journal:
Molecular and cellular biology
Volume:
22
Issue:
1
Pages:
78-93
Publication date:
2002-01-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:260a5b1f-cd87-47bd-b8d8-24a95e83ed33
Source identifiers:
83952
Local pid:
pubs:83952

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