Journal article

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain.

Abstract:: Laddered DNA indicative of apoptosis was observed in the CA1 layer of hippocampus and in dorsolateral striatum following a global cerebral ischemic insult produced by transient two vessel occlusion in rats. The extent of this DNA damage was proportional to the duration of the ischemic episode. Breaks in DNA were demonstrated in situ in sections from post-ischemic brain in neurons of the hippocampal CA1 which undergo selective neuronal death but not in other cell types. It is concluded that there is an apoptotic component to selective neuronal death following global ischemia in rat brain.

Publication status:: Published

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APA Style

MacManus, J., Buchan, A., Hill, I., Rasquinha, I., & Preston, E. (1993). Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain. Neuroscience Letters, 164(1-2), 89–92.

MLA Style

MacManus, J., et al. “Global Ischemia Can Cause DNA Fragmentation Indicative of Apoptosis in Rat Brain.” Neuroscience Letters, vol. 164, no. 1-2, 1993, pp. 89–92.

Chicago Style

MacManus, J, A Buchan, I Hill, I Rasquinha, and E Preston. 1993. “Global Ischemia Can Cause DNA Fragmentation Indicative of Apoptosis in Rat Brain.” Neuroscience Letters 164 (1-2): 89–92.
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Publisher copy:: 10.1016/0304-3940(93)90864-h

Authors

+ MacManus, J More by this author

Role:: Author

+ Buchan, A More by this author

Institution:: University of Oxford
Division:: MSD
Department:: RDM
Sub department:: Stroke and Geratology
Role:: Author

+ Hill, I More by this author

Role:: Author

+ Rasquinha, I More by this author

Role:: Author

+ Preston, E More by this author

Role:: Author

Journal:: Neuroscience letters More from this journal
Volume:: 164
Issue:: 1-2
Pages:: 89-92
Publication date:: 1993-12-01
DOI:: 10.1016/0304-3940(93)90864-h
EISSN:: 1872-7972
ISSN:: 0304-3940

Language:: English
Keywords:: Ethidium

Histocytochemistry

Apoptosis

DNA Damage

Male

Animals

Brain Ischemia

Brain

Rats

Rats, Sprague-Dawley
Pubs id:: pubs:80185
UUID:: uuid:26066922-4cb2-4e48-bd22-747378919e5d
Local pid:: pubs:80185
Source identifiers:: 80185
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 1993

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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