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Structure of Staphylococcus aureus cytidine monophosphate kinase in complex with cytidine 5'-monophosphate.

Abstract:

The crystal structure of Staphylococcus aureus cytidine monophosphate kinase (CMK) in complex with cytidine 5'-monophosphate (CMP) has been determined at 2.3 angstroms resolution. The active site reveals novel features when compared with two orthologues of known structure. Compared with the Streptococcus pneumoniae CMK solution structure of the enzyme alone, S. aureus CMK adopts a more closed conformation, with the NMP-binding domain rotating by approximately 16 degrees towards the central po...

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Publication status:
Published

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Publisher copy:
10.1107/s174430910602447x

Authors


Journal:
Acta crystallographica. Section F, Structural biology and crystallization communications
Volume:
62
Issue:
Pt 8
Pages:
710-715
Publication date:
2006-08-01
DOI:
EISSN:
1744-3091
ISSN:
1744-3091
Source identifiers:
72635

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