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Journal article

Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging.

Abstract:

Targeted therapies have yet to have significant impact on the survival of patients with bladder cancer. In this study, we focused on the urea cycle enzyme argininosuccinate synthetase 1 (ASS1) as a therapeutic target in bladder cancer, based on our discovery of the prognostic and functional import of ASS1 in this setting. ASS1 expression status in bladder tumors from 183 Caucasian and 295 Asian patients was analyzed, along with its hypothesized prognostic impact and association with clinicopa...

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Publication status:
Published

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Journal:
Cancer research
Volume:
74
Issue:
3
Pages:
896-907
Publication date:
2014-02-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:25fd3be9-299a-4da7-8257-526825c8c880
Source identifiers:
445842
Local pid:
pubs:445842

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