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Distinct origins of adult and embryonic blood in Xenopus.

Abstract:

Whether embryonic and adult blood derive from a single (yolk sac) or dual (yolk sac plus intraembryonic) origin is controversial. Here, we show, in Xenopus, that the yolk sac (VBI) and intraembryonic (DLP) blood compartments derive from distinct blastomeres in the 32-cell embryo. The first adult hematopoietic stem cells (HSCs) are thought to form in association with the floor of the dorsal aorta, and we have detected such aortic clusters in Xenopus using hematopoietic markers. Lineage tracing...

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Publication status:
Published

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Authors


Ciau-Uitz, A More by this author
Walmsley, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, BHF Centre of Research Excellence
Journal:
Cell
Volume:
102
Issue:
6
Pages:
787-796
Publication date:
2000-09-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:25f7923e-de68-46cf-bb3c-494641a92763
Source identifiers:
106466
Local pid:
pubs:106466

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