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Messenger RNAs that are not synthesized by RNA polymerase II can be 3' end cleaved and polyadenylated.

Abstract:

The poly(A) tail of influenza virus mRNAs is synthesized by the viral RNA polymerase by reiterative copying of a U5-7 sequence near the 5' end of the viral RNA (vRNA) template. We have engineered a vRNA molecule by replacing its viral U6 poly(A) site with a negative-sense eukaryotic polyadenylation signal. The vRNA was transcribed by the viral RNA polymerase and the transcription product was processed by the cellular 3' end processing machinery in vivo. According to the current model, 3' end ...

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Publication status:
Published

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Publisher copy:
10.1093/embo-reports/kvd111

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Mikulasova, A More by this author
Mingay, LJ More by this author
Brownlee, GG More by this author
Journal:
EMBO reports
Volume:
1
Issue:
6
Pages:
513-518
Publication date:
2000-12-05
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
URN:
uuid:25f69a0c-6718-41d5-aef1-35a700b8e855
Source identifiers:
11960
Local pid:
pubs:11960

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