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Cnn dynamics drive centrosome size asymmetry to ensure daughter centriole retention in Drosophila neuroblasts.

Abstract:

Centrosomes comprise a pair of centrioles surrounded by an amorphous network of pericentriolar material (PCM). In certain stem cells, the two centrosomes differ in size, and this appears to be important for asymmetric cell division [1, 2]. In some cases, centrosome asymmetry is linked to centriole age because the older, mother centriole always organizes more PCM than the daughter centriole, thus ensuring that the mother centriole is always retained in the stem cell after cell division [3]. Th...

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Publication status:
Published

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Publisher copy:
10.1016/j.cub.2010.11.055

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Current biology : CB
Volume:
20
Issue:
24
Pages:
2187-2192
Publication date:
2010-12-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:25f3ae0f-27e5-4004-9dd4-5afac554fb1e
Source identifiers:
223395
Local pid:
pubs:223395

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