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Tau phosphorylation in human brain: Relationship to behavioral disturbance in dementia

Abstract:

Agitation and aggressive behavior are common symptoms of Alzheimer's disease (AD), and tangle density in frontal cortex is a possible regional substrate of these behaviors. To investigate this further, 16 AD patients, 8 patients with non-AD dementia, and 13 age-matched control subjects for frontal cortex and, respectively, 21, 7, and 6 patients for parietal cortex were analyzed for tau and phospho-tau by enzyme-linked immunosorbent assay (ELISA). Agitation/aggression was determined by the Pre...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Neurobiology of Aging
Volume:
33
Issue:
12
Pages:
2798-2806
Publication date:
2012-12-05
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
URN:
uuid:25edf3d7-baf3-442b-ac27-0596100ca727
Source identifiers:
354907
Local pid:
pubs:354907

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