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Journal article

The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure

Abstract:

SIRT1 (silent information regulator 2 homolog 1) is a crucial cellular survival protein especially in oxidative stress environments, and has been thought to locate within the nuclei, but also known to shuttle between cytoplasm and nuclei in some cell types. Here, we show for the first time the dynamics of SIRT1 in the presence of single or concurrent cigarette smoke extract (CSE) exposure in human bronchial epithelial cells (HBEC). In BEAS-2B HBEC or primary HBEC, SIRT1 was localized predomin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0193921

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
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Contributors

Role:
Editor
Banyu Life Science Foundation International fellowship More from this funder
Pulmocide Ltd More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
13
Issue:
3
Pages:
e0193921
Publication date:
2018-03-06
Acceptance date:
2018-02-21
DOI:
EISSN:
1932-6203
Pubs id:
pubs:828828
URN:
uri:25e47997-25a2-424d-8e68-2b4518253dfb
UUID:
uuid:25e47997-25a2-424d-8e68-2b4518253dfb
Local pid:
pubs:828828

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