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Journal article

Lack of effect of CCKB receptor antagonists in ethological and conditioned animal screens for anxiolytic drugs.

Abstract:

The effects of the CCKB receptor antagonists L-365,260, CI-988 and L-740,093, a new compound with improved bioavailability and CNS penetration, were assessed for anxiolytic-like effects in three rat anxiolytic screens sensitive to benzodiazepines, the elevated plus maze (EPM), conditioned suppression of drinking (CSD) and conditioned emotional response (CER) tests. In the EPM, L-740,093 (0.1-1.0 mg/kg), L-365,260 (0.00001-10.0 mg/kg), and CI-988 (0.01-1.0 mg/kg) did not increase the time spen...

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Publication status:
Published

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Publisher copy:
10.1007/bf02245597

Authors


Dawson, GR More by this author
Rupniak, NM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
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Journal:
Psychopharmacology
Volume:
121
Issue:
1
Pages:
109-117
Publication date:
1995-09-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:25d53843-3e81-4da9-a500-af299b5248ad
Source identifiers:
6125
Local pid:
pubs:6125

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