- Abstract:
-
The effects of the CCKB receptor antagonists L-365,260, CI-988 and L-740,093, a new compound with improved bioavailability and CNS penetration, were assessed for anxiolytic-like effects in three rat anxiolytic screens sensitive to benzodiazepines, the elevated plus maze (EPM), conditioned suppression of drinking (CSD) and conditioned emotional response (CER) tests. In the EPM, L-740,093 (0.1-1.0 mg/kg), L-365,260 (0.00001-10.0 mg/kg), and CI-988 (0.01-1.0 mg/kg) did not increase the time spen...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/bf02245597
-
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- Journal:
- Psychopharmacology
- Volume:
- 121
- Issue:
- 1
- Pages:
- 109-117
- Publication date:
- 1995-09-05
- DOI:
- EISSN:
-
1432-2072
- ISSN:
-
0033-3158
- URN:
-
uuid:25d53843-3e81-4da9-a500-af299b5248ad
- Source identifiers:
-
6125
- Local pid:
- pubs:6125
- Copyright date:
- 1995
Journal article
Lack of effect of CCKB receptor antagonists in ethological and conditioned animal screens for anxiolytic drugs.
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