Journal article icon

Journal article

SYNTHESIS FROM D-MANNOSE OF 1,4-DIDEOXY-1,4-IMINO-L-RIBITOL AND OF THE ALPHA-MANNOSIDASE INHIBITOR 1,4-DIDEOXY-1,4-IMINO-D-TALITOL

Abstract:
The syntheses of 1,4-dideoxy-l,4-imino-L-ribitol and of 1,4-dideoxy-l,4-imino-D-talitol from D-mannose are described. 1,4-Dideoxy-l,4-imino-D-talitol is a specific and competitive inhibitor of human liver α-mannosidase in vitro and also blocks the lysosomal catabolism of asparigine-linked glycans of glycoproteins in vivo. © 1988.
Publication status:
Published

Actions


Access Document


Authors


Journal:
TETRAHEDRON
Volume:
44
Issue:
9
Pages:
2649-2655
Publication date:
1988-01-01
DOI:
ISSN:
0040-4020
URN:
uuid:25c19704-b153-4b5f-9263-decfa6eca718
Source identifiers:
42903
Local pid:
pubs:42903
Language:
English

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP