Journal article icon

Journal article

Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo.

Abstract:

P-cadherin is normally expressed in the basal layer of squamous epithelia and absent from the healthy intestine and colon. We have previously shown it to be expressed in all inflamed, hyperplastic, and dysplastic intestinal and colonic mucosa. This study aimed to better understand the mechanisms controlling the expression of P-cadherin and the biological effects of its ectopic presence in the intestine and colon. We investigated the CpG methylation status of the P-cadherin (CDH3) promoter and...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Milicic, A More by this author
Harrison, LA More by this author
Goodlad, RA More by this author
Nicholson, AM More by this author
Expand authors...
Journal:
Cancer research
Volume:
68
Issue:
19
Pages:
7760-7768
Publication date:
2008-10-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:25c074a6-b073-4a10-8322-39414a59b6d7
Source identifiers:
72271
Local pid:
pubs:72271

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP