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CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression.

Abstract:

The CD40-CD40 ligand (CD40L) interaction is a key event in the initiation of an adaptive immune response, and as such the therapeutic value of CD40L blockade has been studied in many experimental models of tissue transplantation and autoimmune disease. In rodents, transplantation of allogeneic tissues under the cover of anti-CD40L Abs has resulted in prolonged graft survival but not tolerance. In this report, we show that failure to induce tolerance probably results from the inability of anti...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
163
Issue:
9
Pages:
4805-4810
Publication date:
1999-11-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:25be9fc5-620e-4de0-a4ad-ffdbec80a627
Source identifiers:
20898
Local pid:
pubs:20898

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