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A biomathematical modeling approach to central nervous system radioligand discovery and development.

Abstract:

UNLABELLED: The development of a successful PET or SPECT molecular imaging probe is a complex, time-consuming, and expensive process that suffers from high attrition. To address this problem, we have developed a biomathematical modeling approach that aims to predict the in vivo performance of radioligands directly from in silico/in vitro data. METHODS: The method estimates the in vivo nondisplaceable and total uptake of a ligand in a target tissue using a standard input function and a 1-tiss...

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Publication status:
Published

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Publisher copy:
10.2967/jnumed.109.063800

Authors


Journal:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume:
50
Issue:
10
Pages:
1715-1723
Publication date:
2009-10-05
DOI:
EISSN:
1535-5667
ISSN:
0161-5505
URN:
uuid:25b40689-5c4a-4027-9892-04079c8b53d2
Source identifiers:
64925
Local pid:
pubs:64925

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