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Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels.

Abstract:

Sulfonylureas stimulate insulin secretion from pancreatic beta-cells by closing ATP-sensitive K+ (K(ATP)). The beta-cell and cardiac muscle K(ATP) channels have recently been cloned and shown to possess a common pore-forming subunit (Kir6.2) but different sulfonylurea receptor subunits (SUR1 and SUR2A, respectively). We examined the mechanism underlying the tissue specificity of the sulfonylureas tolbutamide and glibenclamide, and the benzamido-derivative meglitinide, using cloned beta-cell (...

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Publication status:
Published

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Publisher copy:
10.2337/diabetes.47.9.1412

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Diabetes
Volume:
47
Issue:
9
Pages:
1412-1418
Publication date:
1998-09-01
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Source identifiers:
18406

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