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Journal article

Trastuzumab-resistant breast cancer cells remain sensitive to the auger electron-emitting radiotherapeutic agent 111In-NLS-trastuzumab and are radiosensitized by methotrexate.

Abstract:

UNLABELLED: Our goals in this study were to determine whether (111)In-trastuzumab coupled to peptides harboring nuclear localizing sequences (NLSs) could kill trastuzumab-resistant breast cancer cell lines through the emission of Auger electrons and whether the combination of radiosensitization with methotrexate (MTX) would augment the cytotoxicity of this radiopharmaceutical. METHODS: Trastuzumab was derivatized with sulfosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate for reacti...

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Publication status:
Published

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Publisher copy:
10.2967/jnumed.108.051771

Authors


Costantini, DL More by this author
Bateman, K More by this author
McLarty, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Reilly, RM More by this author
Journal:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume:
49
Issue:
9
Pages:
1498-1505
Publication date:
2008-09-05
DOI:
EISSN:
1535-5667
ISSN:
0161-5505
URN:
uuid:25abcb00-d86a-4513-a069-c4eda68b71c4
Source identifiers:
131363
Local pid:
pubs:131363

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